![]() ![]() ![]() MethodsĮTIV and total brain volume for 62 participants were calculated on 1.5-T, T1-weighted MR images using FreeSurfer (version 6.0.0). Our null hypothesis was that no correlation would remain between eTIV and total brain volume when controlling for intracranial volume. If eTIV is unbiased, variance beyond that explained by intracranial volume should be random. Estimated intracranial volume (eTIV) from FreeSurfer is not segmentation-based but calculated from the alignment of the input magnetic resonance (MR) images to the MNI305 brain atlas, an approach that could lead to a bias by total brain volume.
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